Fabry disease and the clinical spectrum of angiokeratomas.

only able to apply a single session in the present case owing to the appearance of side effects, and this may explain the incomplete response obtained. However, it is also possible that the immunomodulatory effect of PDT and the inflammation already present in the lesion (visible in the clinical and histological images) may have favored a good therapeutic response with just 1 session. Ulceration is a rare adverse event, and its appearance was probably due in some measure to the fact that the patient was an elderly woman and the leg was exposed to sunlight after treatment, contrary to express instructions. In conclusion, we report a case of porokeratosis of Mibelli in which treatment with PDT obtained a partial response. Nevertheless, because the results achieved with photodynamic therapy in the treatment of porokeratosis are highly varied, we believe that further studies with larger series of cases are needed if we are to reach clear conclusions regarding its utility in this setting.